منابع مشابه
Walking Atop the Cliffs
Despite a growing body of descriptive, theoretical and practical knowledge about Information Systems Development (ISD), large-scale information system development and implementation projects still fail in high numbers. The deeper causes of such failures are only partially understood. This study uses an action research approach in which prescriptions and recommendations drawn from research on an...
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The retreat of cliffs may constitute the dominant erosional response to base‐level fall in arid settings underlain by horizontally‐bedded sedimentary rock. These vertical cliffs typically loom above a relatively straight bedrock slope (‘plinth’) that is mantled with a thin layer of sediment and perched near the angle of repose. In detail, a plinth consists of a system of quasi‐parallel ridges a...
متن کاملFrom activity cliffs to target-specific scoring models and pharmacophore hypotheses.
The role of activity cliffs in drug discovery projects is certainly two-edged: on the one hand, they often lead to the failure of QSAR modeling techniques; on the other, they are highly valuable for identifying key aspects of SARs. In the presence of activity cliffs the results of purely ligand-based QSAR approaches often remain puzzling, and the resulting models have limited predictive power. ...
متن کاملQuantifying “Cliffs” in Design Space
Purpose: This paper studies the regions of parameter space of engineering design in which performance is sensitive to design parameters. Some of these parameters (for example, the dimensions and compositions of components) constitute the design, but others are intrinsic properties of materials or Nature. The paper is concerned with narrow regions of parameter space, “cliffs”, in which performan...
متن کاملActivity cliffs in drug discovery: Dr Jekyll or Mr Hyde?
The impact activity cliffs have on drug discovery is double-edged. For instance, whereas medicinal chemists can take advantage of regions in chemical space rich in activity cliffs, QSAR practitioners need to escape from such regions. The influence of activity cliffs in medicinal chemistry applications is extensively documented. However, the 'dark side' of activity cliffs (i.e. their detrimental...
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ژورنال
عنوان ژورنال: Future Science OA
سال: 2017
ISSN: 2056-5623
DOI: 10.4155/fsoa-2017-0065